Células linfoides innatas: actualización de avances en inmunología
Autores
Alejandro Ulloa-Morales, Yadel Centeno-Ureña
Resumen
Las células linfoides innatas (CLIs) son un nuevo grupo de células inmunes definidas por la falta de receptores antígeno-específicos y la ausencia de selección clonal al ser estimuladas. Como respuesta a señales tisulares, las CLIs producen citoquinas que dirigen la respuesta inmune adaptativa de forma específica al tipo de lesión. Actualmente, las CLIs son clasificadas en tres grupos según su fenotipo y funciones. A pesar de que aún no se conocen claramente las interacciones entre el microambiente tisular y el papel que desempeñan las CLIs en la regulación de los tejidos grasos y la termogénesis, el conocimiento generado por su estudio puede resultar en nuevas opciones terapéuticas para la regulación y optimización de las respuestas inmunes.
Palabras clave
Células linfoides innatas, citoquinas, respuesta innata, respuesta adaptativa, termogénesisAbstract
Innate lymphoid cells (ILCs) are a new group of immune cells defined by the lack of antigen-specific receptors and the absence of clonal selection when stimulated. In response to tissue signals, ILCs produce cytokines that target the adaptive immune response specifically to the type of injury. ILCs are currently classified into three groups according to their phenotype and functions. Although the interactions between the tissue microenvironment and the role that CLIs play in the regulation of fatty tissues and thermogenesis are still not clear, the knowledge generated by their study may result in new therapeutic options for the regulation and optimization of immune responses.
Key words
Innate lymphoid cells, cytokines, innate response, adaptive response, thermogenesisTexto completo
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